Glucagonoma other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2] Mohammed Abdelwahed M.D[3]
Overview
Other diagnostic studies for glucagonoma include biopsy, which demonstrates epidermal necrosis, subcorneal pustules, either isolated or associated with necrosis of the epidermis, confluent parakeratosis, epidermal hyperplasia and marked papillary dermal angioplasia, and suppurative folliculitis.
Other Diagnostic Studies
Invasive investigations may be needed to localize tumors at particular regions of the pancreas for treatment planning.
Arterial stimulation venous sampling
Transhepatic portal venous sampling involves a selective injection of a stimulating secretin for glucagonoma into arterial supply of the pancreas with a sampling of the hepatic veins. 51 It is highly sensitive 72
Biopsy
- a skin biopsy may demonstrate necrolytic migratory erythema in patients with glucagonoma.
- Findings on biopsy suggestive of glucagonoma include:[1]
- Epidermal necrosis
- Subcorneal pustules, either isolated or associated with necrosis of the epidermis
- Confluent parakeratosis
- Epidermal hyperplasia, and marked papillary dermal angioplasia
- Suppurative folliculitis
References
- ↑ Kheir SM, Omura EF, Grizzle WE, Herrera GA, Lee I (1986). "Histologic variation in the skin lesions of the glucagonoma syndrome". Am J Surg Pathol. 10 (7): 445–53. PMID 3014912.