Acromegaly natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

• If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
• Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

• If left untreated, 30% of patients with acromegaly may progress to develop cardiovascular manifestations, pulmonary dysfunction, and cerebral complications. These comorbidities will increase the mortality rate.

Complications

• Common complications of acromegaly include:
  • Arthritis
  • Cardiovascular disease
  • Carpal tunnel syndrome
  • Colonic polyps
  • Glucose intolerance or diabetes
  • High blood pressure
  • Hypopituitarism
  • Sleep apnea
  • Spinal cord compression
  • Uterine fibroids
  • Vision abnormalities

Prognosis

• Prognosis of acromegaly is generally good with transsphenoidal surgery and the postoperative treatment.

References

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