Sheehan's syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
[Test] is usually normal among patients with [disease name].
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

Laboratory findings consistent with the diagnosis of Sheehan syndrome include:
- Hyponatremia^[1]^[2]^[3]
- Hypokalemia
- Hypocalcemia
- Hypomagnesemia
- Hypophosphatemia
- Anemia^[3]
- Pancytopenia^[4]
- Eosinophilia^[5]
- Hypoalbuminemia
- Low fasting plasma glucose
- Elevated serum SGOT
- Thrombocytopenia
- Decreased levels of anterior pituitary hormones in blood.
Most sensitive test is inadequate prolactin and gonadotropin responses to stimulation.
Baseline and stimulated anterior pituitary hormone level measurements.

↑ Shoji M, Kimura T, Ota K, Ohta M, Sato K, Yamamoto T, Funyu T, Mori T, Tateyama M, Abe K (1996). "Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia". Intern. Med. 35 (5): 427–31. PMID 8797063.
↑ Putterman C, Almog Y, Caraco Y, Gross DJ, Ben-Chetrit E (1991). "Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia". Am. J. Obstet. Gynecol. 165 (5 Pt 1): 1330–3. PMID 1957856.
↑ ^3.0 ^3.1 Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB (2009). "A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia". Acta Biomed. 80 (1): 73–6. PMID 19705625.
↑ Laway BA, Bhat JR, Mir SA, Khan RS, Lone MI, Zargar AH (2010). "Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review)". Ann. Hematol. 89 (3): 305–8. doi:10.1007/s00277-009-0804-9. PMID 19697029.
↑ Ratarasarn C, Rajatanavin R, Himathongkam T (1989). "Salient clinical features of Sheehan's syndrome". J Med Assoc Thai. 72 (1): 41–7. PMID 2723566.