Sheehan's syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Iqra Qamar M.D.[2]

Overview

Sheehan syndrome, if left untreated lead to mitral regurgitation, pericardial effusion and diminished LVM.^[1]
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Sheehan syndrome usually results in anterior pituitary shrinkage within 20 days followed by disappearance of pituitary tissue in 6-8 week resulting in hypopituitarism and empty sella syndrome.
The symptoms of Sheehan's syndrome can develop during immediate post-puerperal period to years after delivery.
It may result in sparing or reversal of gonadotropic dysfunction as few cases of successful pregnancies have been reported following sheehan's syndrome.^[2]^[3]
If left untreated,lead to mitral regurgitation, pericardial effusion and diminished LVM, adrenal crisis, pituitay hypopituitarism and empty sella syndrome.^[1]

Prognosis is generally good, and results in reversal of symptoms once respective hormones are being replaced.

↑ ^1.0 ^1.1 Laway BA, Ramzan M, Allai MS, Wani AI, Misgar RA (2016). "CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY". Endocr Pract. 22 (9): 1096–103. doi:10.4158/EP161262.OR. PMID 27359291.
↑ Zargar AH, Masoodi SR, Laway BA, Sofi FA, Wani AI (1998). "Pregnancy in Sheehan's syndrome: a report of three cases". J Assoc Physicians India. 46 (5): 476–8. PMID 11273296.
↑ Moreira AC, Zanini Maciel LM, Foss MC, Tabosa Veríssimo JM, Iazigi N (1984). "Gonadotropin secretory capacity in a patient with Sheehan's syndrome with successful pregnancies". Fertil. Steril. 42 (2): 303–5. PMID 6745465.