Gynecomastia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]
Overview
If left untreated patients with gynecomastia may progress to develop psychosocial stresses and rarely breast cancer. The majority of physiological gynecomastia is self-limited. Pathological gynecomastia has an excellent prognosis and responds well to treatment. Pharmacological gynecomastia responds very well to the cessation of the offending agent.
Natural History, Complications, and Prognosis
Natural History
- The signs and symptoms of gynecomastia typically develop in neonatal, pubertal age or in the elderly.[1][2][3]
- Without treatment gynecomastia has some associated risk of breast cancer, however, the majority of physiological gynecomastia resolves in months to years time.
Complications
Complications of gynecomastia include:[4][5][6]
- Persistent pubertal gynecomastia
- Breast cancer
- Psychological stress like depression, reduced self-esteem, and body dissatisfaction.
Prognosis
- Physiological gynecomastia has an excellent prognosis and the majority of physiological gynecomastia resolve spontaneously.
- Pathological gynecomastia also responds well to treatment or removal of the underlying cause.
- Pharmacological gynecomastia responds very well to the cessation of the offending agent.
- Persistent gynecomastia can cause psychological stress and increases the risk of breast cancer.[7][8][9]
References
- ↑ Braunstein GD (1993). "Gynecomastia". N Engl J Med. 328 (7): 490–5. doi:10.1056/NEJM199302183280708. PMID 8421478.
- ↑ Biro FM, Lucky AW, Huster GA, Morrison JA (1990). "Hormonal studies and physical maturation in adolescent gynecomastia". J. Pediatr. 116 (3): 450–5. PMID 2137877.
- ↑ Lemaine V, Cayci C, Simmons PS, Petty P (2013). "Gynecomastia in adolescent males". Semin Plast Surg. 27 (1): 56–61. doi:10.1055/s-0033-1347166. PMC 3706045. PMID 24872741.
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID org/10.1016/j.amjmed.2016.01.009 Check
|pmid=value (help). - ↑ Ordaz DL, Thompson JK (2015). "Gynecomastia and psychological functioning: A review of the literature". Body Image. 15: 141–8. doi:10.1016/j.bodyim.2015.08.004. PMID 26408934.
- ↑ Rew L, Young C, Harrison T, Caridi R (2015). "A systematic review of literature on psychosocial aspects of gynecomastia in adolescents and young men". J Adolesc. 43: 206–12. doi:10.1016/j.adolescence.2015.06.007. PMID 26151806.
- ↑ Wiesman, IM.; et al. "Gynecomastia: An Outcome Analysis".
- ↑ Li CC, Fu JP, Chang SC, Chen TM, Chen SG (2012). "Surgical treatment of gynecomastia: complications and outcomes". Ann Plast Surg. 69 (5): 510–5. doi:10.1097/SAP.0b013e318222834d. PMID 21712702.
- ↑ Choi BS, Lee SR, Byun GY, Hwang SB, Koo BH (2017). "The Characteristics and Short-Term Surgical Outcomes of Adolescent Gynecomastia". Aesthetic Plast Surg. doi:10.1007/s00266-017-0886-z. PMID 28451801.