Celiac disease screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]

Overview

Screening with tissue transglutaminase (tTG) IgA test is recommended for symptomatic high risk celiac disease patients.

Screening

• Screening in asymptomatic persons is not recommended.
• Screening is recommended for symptomatic and high risk patients with positive family history in first and second degree relatives also in patients with other autoimmune diseases such as, type 1 diabetes mellitus, inflammatory luminal gastrointestinal disorders, Down syndrome, Turner syndrome, IgA deficiency, and IgA nephropathy.
• Screening method for celiac disease is tissue transglutaminase (tTG) IgA test.