Rift valley fever causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

  • RVF is caused by the Rift Valley fever virus or RVFV, which belongs to the Bunyaviridae family.
  • The genetic composition of the virus is a single-stranded RNA consisting of three segments (L, M and S) out of which L and M possess a negative charge while the S segment has both sense and antisense orientation.[1]
  • The virus’ RNA polymerase is coded by the L component which is responsible for replication and transcription of messenger RNA (mRNA) while glycoproteins and protein are encoded via the M segment. [2]
  • Nucleoproteins and non-structural proteins are coded by the S segment in its antisense and sense orientation respectively.

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References

  1. Giorgi C. et al. 1991. Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian sandfly fever, and Uukuniemi viruses. Virology 180:738–753
  2. Gerrard S. R. and Nichol S. T.. 2007. Synthesis, proteolytic processing and complex formation of N-terminally nested precursor proteins of the Rift Valley fever virus glycoproteins. Virology 357:124–133.
  3. 3.0 3.1 "Public Health Image Library (PHIL)".

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