Sandbox:Amd

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Adrenal Insufficiency

Disease	Clinical history/findings							Causes	Investigations/ Laboratory findings			Medical management	Surgical management
	Hypotension	Skin pigmentation/ findings	Hypoglycemia	Anorexia	Abdominal pain	Muscle weakness	Other history/ findings		Hyponatremia	Cortisol levels	Gold Standard
Differentiating Primary from Secondary adrenal insufficiency
Primary adrenal insufficiency	✔	✔	✔	✔	✔			Autoimmune/idiopathic Infections- Tuberculosis, histoplasmosis	✔	↓	Cosyntropin/ ACTH stimulation test
Secondary adrenal insufficiency	✔	-						Hypopituitarism- Tumors, infections. hemorrhage/trauma Drugs- Chronic steroid therapy and its withdrawal, Opiates Genetic- Combined pituitary hormone deficiency (CPHD), POMC (Proopiomelanocortin) gene deficiency
Differentiating Adrenal Insufficiency from other diseases