Hypogonadism causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Luke Rusowicz-Orazem, B.S.
Overview
Hypogonadism is commonly caused by congenital, acquired genetic and endocrinological conditions. Life threatening causes may include malignancies and must take in to consideration during patient approach.[1][2]
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. The following diseases are life threatening causes of hypogonadism:
- Astrocytoma
- Chronic renal failure
- Papillary renal cell carcinoma
- Postinfectious lesions of the central nervous system (CNS)
- Ureter cancer
- Urinary system cancer
- Wilms tumor
- Infective endocarditis
Common Causes
- Anorchidism
- Chemotherapy
- Cryptorchidism
- FSH beta subunit mutation (follicle stimulating hormone)
- FSH receptor mutation
- Klinefelter Syndrome
- LH (luteinizing hormone) beta subunit mutation
- LH receptor mutation
- LH resistance
- Radiation therapy
- Sertoli-cell-only syndrome
- Testicular biosynthetic defects
- Autoimmune oophoritis
- Chemotherapy
- Familial and sporadic XX gonadal dysgenesis and its variants
- Familial and sporadic XY gonadal dysgenesis and its variants
- FSH beta subunit mutation (follicle stimulating hormone)
- FSH receptor mutation
- Galactosemia
- Glycoprotein syndrome type 1
- LH (luteinizing hormone) beta subunit mutation
- LH/human chorionic gonadotropin resistance
- LH receptor mutation
- Noonan Syndrome
- Premature menopause
- Polycystic ovarian disease
- Radiation therapy
- Resistant ovary
- Turner Syndrome
- Astrocytoma
- Bardet-Biedl Syndrome
- Congenital adrenal hypoplasia
- Congenital hypogonadotropic hypogonadism
- Craniofacial anomalies
- Craniopharyngioma
- Exercise-induced amenorrhea
- Functional gonadotropin deficiency
- Gaucher Disease
- Germinoma
- Head trauma
- Hyperprolactinemia
- Hypothalamic glioma
- Isolated FSH deficiency
- Isolated LH deficiency
- Kallmann Syndrome
- Langerhans histiocytosis
- Laurence-Moon Syndrome
- Marijuana use
- Optic glioma
- Other germ cell tumors
- Pituitary tumor
- Postinfectious lesions of the central nervous system (CNS)
- Prader-Willi Syndrome
- Radiation therapy
- Vascular abnormalities of the CNS
Causes by Organ System
Causes in Alphabetical Order
- 17α-hydroxylase deficiency
- 17β-hydroxysteroid dehydrogenase iii deficiency
- 20-lyase deficiency
- 48, xxxy aneuploidy
- 48, xxyy aneuploidy
- 4h syndrome
- Acrocephalopolysyndactyly type 2
- Adiposogenital dystrophy
- Adrenal hypoplasia
- Aids
- Alcohol
- Alkylating agents
- Alström syndrome
- Amyloidosis
- Anorchia
- Anorchidism
- Anorexia nervosa
- Antiandrogens
- Aromatase deficiency
- Astrocytoma
- Autoimmune damage
- Autoimmune oophoritis
- Autoimmune polyendocrine syndrome type 2
- Autoimmunity
- Bardet-biedl syndrome
- Belgian type mental retardation
- Blepharophimosis syndrome
- Borjeson-forssman-lehmann syndrome
- Boucher-neuhäuser syndrome
- Cardiofaciocutaneous syndrome
- Ccfdn syndrome
- Charge syndrome
- Chemotherapy
- Chronic renal failure
- Chronic systemic illnesses
- Combined pituitary hormone deficiency
- Congenital adrenal hypoplasia
- Congenital hypogonadotropic hypogonadism
- Craniofacial anomalies
- Craniopharyngioma
- Cryptorchism
- Cytotoxic therapeutic agents
- Didmoad syndrome
- Disorders of androgen synthesis
- Dystrophia myotonica type 2
- Environmental toxins
- Epididymo-orchitis
- Ethanol
- Exercise-induced amenorrhea
- Fsh receptor deficiency
- Fsh beta subunit mutation (follicle stimulating hormone)
- Fsh receptor mutation
- Functional gonadotropin deficiency
- Galactose-1-phosphate uridyltransferase deficiency
- Galactosemia
- Gaucher disease
- Germinoma
- Glucocorticoids
- Glycoprotein syndrome type 1
- Gonadal dysgenesis
- Gordon holmes syndrome
- Growth hormone secreting pituitary adenoma
- Hartsfield syndrome
- Head trauma
- Hemochromatosis
- Hepatic cirrhosis
- Hyperprolactinemia
- Hypogonadic hypogonadism
- Hypogonadotrophic hypogonadism
- Hypopituitarism
- Hypothalamic glioma
- Idiopathic
- Image syndrome
- Infections
- Isolated fsh deficiency
- Isolated lh deficiency
- Jaffe-campanacci syndrome
- Kallmann syndrome
- Ketoconazole
- Klinefelter syndrome
- Langerhans histiocytosis
- Laurence-moon syndrome
- Lepromatous leprosy
- Leptin deficiency
- Leukoencephalopathy
- Lh (luteinizing hormone) beta subunit mutation
- Lh receptor mutation
- Lh resistance
- Lipoid congenital adrenal hyperplasia
- Malouf syndrome
- Marijuana use
- Marinesco-sjogren-garland syndrome
- Martsolf syndrome
- Mobius syndrome
- Mosaicism
- Mumps
- Myotonic dystrophy
- Noonan syndrome
- Opioids
- Optic glioma
- Orchidectomy
- Orchitis
- Other germ cell tumors
- Ovarian resistance syndrome
- Ovarian torsion
- Panhypopituitarism
- Pituitary tumor
- Poems syndrome
- Polycystic ovarian disease
- Postinfectious lesions of the central nervous system (cns)
- Prader-willi syndrome
- Premature ovarian failure
- Premature menopause
- Proprotein convertase 1/3 deficiency
- Pseudohypoparathyroidism type 1a
- Radiation therapy
- Radiotherapy
- Renal failure
- Resistant ovary
- Rud syndrome
- Sertoli-cell-only syndrome
- Suramin
- Surgery
- Swyer's syndrome
- Testicular biosynthetic defects
- Testicular torsion
- Toxins
- Trauma
- Turner syndrome
- Varicocele
- Vascular abnormalities of the cns
- Woodhouse-sakati syndrome
- X-linked mental retardation-hypotonic facies syndrome
- Xx gonadal dysgenesis
- Zinc deficiency
- Hemophilia
- Henoch-schonlein purpura
- Hepatitis a
- Hepatitis b
- Hepatitis c
- Hepatorenal tyrosinemia
- Hereditary hemorrhagic telangiectasia
- Hereditary leiomyomatosis
- Herns syndrome
- Honeymoon bladder
- Hypercalciuria
- Hypertension
- Hypocomplementemic urticarial vasculitis
- Idarubicin
- Iga nephropathy
- Immune thrombocytopenic purpura
- Indandione rodenticide poisoning
- Infective endocarditis
- Interstitial nephritis
- Jaundice
- Juniper tar poisoning
- Kidney cancer
- Kidney stones
- Klerat rodenticide poisoning
- Lactate dehydrogenase deficiency
- Lecithin-cholesterol acyltransferase deficiency
- Leiomyomatosis of esophagus
- Leucinosis
- Leukocytoclastic angiitis
- Liver cancer
- Machupo virus
- Malaria
- Malignant rhabdoid tumors
- Maple syrup urine disease
- Matikus rodenticide poisoning
- Medullary sponge kidney
- Meier-blumberg-imahorn syndrome
- Melanoma
- Membranous nephropathy
- Mepacrine
- Methaemoglobinaemia
- Metronidazole
- Milky urine
- Mitoxantrone
- Monosodium methanarsenate
- Mouser rodenticide poisoninge
- Myoglobinuria
- Nail-patella syndrome
- Naked brimcap poisoning
- Naphthalene
- Nefopam
- Neoplastic porphyria tarda
- Nephritis
- Nephrocalcinosis
- Nephropathy
- Nephrosis
- Nitrates
- Norum disease
- Obstructive jaundice
- Oncocytoma
- Oral contraceptives
- Orchitis
- Oxalosis
- Oxamniquine
- Papillary renal cell carcinoma
- Paragonimiases
- Parkinson's disease
- Pelvic fracture
- Pelvic lipomatosis
- Penis cancer
- Penis conditions
- Penis tourniquet syndrome
- Pennyroyal oil
- Peppermint oil
- Petroleum distillates
- Phenazopyridine
- Phenol
- Phenolphthalein
- Phensuximide
- Phosphine
- Phyllodes tumor of the prostate
- Pierson syndrome
- Pindone rodenticide poisoning
- Pixantrone
- Polycystic kidney disease
- Porphyria
- Precalicial canalicular ectasia
- Prostate cancer
- Prostatic abscess
- Prostatitis
- Pyelonephritis
- Quebec platelet disorder
- Ratak plus rodenticide poisoning
- Reflux nephropathy
- Reiter’s syndrome
- Renal abscess
- Renal cancer
- Renal colic
- Renal failure
- Renal hypertension
- Renal mucormycosis
- Renal nutcracker syndrome
- Renal zygmycosis
- Renovascular hypertension
- Rhabdoid tumor
- Rhabdomyolysis
- Rhubarb
- Rifabutin
- Rifampicin
- Rodend rodenticide poisoning
- Rue
- Salcedo syndrome
- Sarcoma botryoides
- Schistosomiasis
- Senna
- Southworth symptom complex
- Spirochetes disease
- Stones
- Stuart factor deficiency
- Sulphasalazine
- Talon rodenticide poisoning
- Thalassemia
- Thrombasthenia
- Thrombocytopathy
- Thrombocytopenia
- Thrombocytopenic purpura
- Torulopsis
- Toxic epidermal necrolysis
- Toxic mushrooms
- Transitional cell carcinoma
- Trichosporin infection
- Tuberculosis
- Turpentine oil
- Urachal cancer
- Urachal cyst
- Urban schosser spohn syndrome
- Ureter cancer
- Urethral cancer
- Urinary disorders
- Urinary stones
- Urinary system cancer
- Urinary tract infections
- Urod-related porphyria cutanea tarda
- Vasculitis hypersensitivity
- Vasculitis
- Volak rodenticide poisoning
- Volid rodenticide poisoning
- Wegener's granulomatosis
- Weil syndrome
- Wilms tumor
- Wilson's disease
- Xanthic urolithiasis
- Xanthine oxydase deficiency
- Xanthinuria
- Yellow fever