Tropheryma whipplei
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
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Whipple's disease Microchapters |
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Diagnosis |
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Tropheryma whipplei On the Web |
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American Roentgen Ray Society Images of Tropheryma whipplei |
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| Tropheryma whipplei La Scola et al 2001 |
Tropheryma whipplei is a bacterium and the causative organism of Whipple's disease.[1] While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[1] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case,[2] but no name was given to the organism until 1991 when the name Tropheryma whippelii was proposed after sections of the bacterial genome were sequenced.[3] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) after deposition in bacterial collections.[1]
Pathogenesis
References
- ↑ 1.0 1.1 1.2 {La Scola B, Fenollar F, Fournier P, Altwegg M, Mallet M, Raoult D (2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int J Syst Evol Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.
- ↑ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and msenteric lymphatic tissues". Johns Hopkins Hosp Bull. 18: 382&ndash, 91.
- ↑ Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med. 327 (5): 293–301. PMID 1377787.