Adrenocortical carcinoma classification
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Diagnosis |
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Adrenocortical carcinoma classification On the Web |
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American Roentgen Ray Society Images of Adrenocortical carcinoma classification |
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Risk calculators and risk factors for Adrenocortical carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]
Overview
Adrenocortical carcinoma can be classified according to hormone production, and histological appearance. ACC may secrete cortisol, aldosterone, testosterone or estrogen. Other variants include oncocytic adrenal cortical carcinoma, myxoid adrenal cortical carcinoma, and carcinosarcoma.
Classification
Adrenocortical carcinomas are classified based on:[1]
Hormones production:
Functional
A Functional adrenocortical carcinoma may produce one or more of the following hormones:[2]
Nonfunctional
A nonfunctional adrenocortical carcinoma does not procuce any of the above hormones.
Histology:
Adrenocortical carcinoma can be classified according to the differentiation of the tissue under the microscope into:
- Well-differentiated
- Intermediate differentiated
- Poorly differentiated
- Anaplastic
Variants:
- Oncocytic adrenal cortical carcinoma
- Myxoid adrenal cortical carcinoma
- Carcinosarcoma
- Adenosquamous adrenocortical carcinoma
- Clear cell adrenal cortical carcinoma
Staging of adrenocortical carcinoma
The AJCC has designated staging by TNM to define adrenocortical carcinoma: [3]
| Stage | Description |
|---|---|
| TX | Primary tumor cannot be assessed |
| T0 | No evidence of primary tumor |
| T1 | Tumor ≤5 cm in greatest dimension limited to the adrenals |
| T2 | Tumor >5 cm in greatest dimension, limited to the adrenals |
| T3 | Tumor of any size with local invasion, but not invading adjacent organs |
| T4 | Tumor of any size with invasion of adjacent organs |
| Stage | Description |
|---|---|
| NX | Regional lymph node cannot be assessed |
| N0 | No regional lymph node metastasis |
| N1 | Regional lymph node metastasis |
| Stage | Description |
|---|---|
| M0 | No distant metastasis |
| M1 | Distant metastasis |
| Stage | T | N | M |
|---|---|---|---|
| I | T1 | N0 | M0 |
| II | T2 | N0 | M0 |
| III | T1 | N1 | M0 |
| T2 | N1 | M0 | |
| T3 | N0 | M0 | |
| IV | T3 | N1 | M0 |
| T4 | N0 | M0 | |
| T4 | N1 | M0 | |
| Any T | Any N | M1 |
A new study showed staging system that incorporates the patient's age better and predicts 5-year survival among patients with stages I/II ACC. Consideration should be given to include age in staging for ACC, because it may better inform providers about treatment and prognosis.[4]
References
- ↑ de Krijger RR, Papathomas TG (2012). "Adrenocortical neoplasia: evolving concepts in tumorigenesis with an emphasis on adrenal cortical carcinoma variants". Virchows Arch. 460 (1): 9–18. doi:10.1007/s00428-011-1166-y. PMC 3267029. PMID 22086150.
- ↑ Ganeshan D, Bhosale P, Kundra V (2012). "Current update on cytogenetics, taxonomy, diagnosis, and management of adrenocortical carcinoma: what radiologists should know". AJR Am J Roentgenol. 199 (6): 1283–93. doi:10.2214/AJR.11.8282. PMID 23169720.
- ↑ Edge SB, Compton CC (2010). "The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM". Ann Surg Oncol. 17 (6): 1471–4. doi:10.1245/s10434-010-0985-4. PMID 20180029.
- ↑ Asare EA, Wang TS, Winchester DP, Mallin K, Kebebew E, Sturgeon C (2014). "A novel staging system for adrenocortical carcinoma better predicts survival in patients with stage I/II disease". Surgery. 156 (6): 1378–85, discussion 1385-6. doi:10.1016/j.surg.2014.08.018. PMID 25456914.