Carcinoid syndrome historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Carcinoid syndrome was first described by Siegfried Oberndorfer, a German pathologist in 1907. Endocrine related properties of carcinoid syndrome was described by Gosset and Masson in 1914.[1]
Historical Perspective
- Theodor Langhans (1839–1915) was the first to describe the histology of a carcinoid tumor in 1867.
- Carcinoid tumour was first described in 1907 by Siegfried Oberndorfer, a German pathologist at the University of Munich.
- Siegfried Oberndorfer refered the carcinoid tumor as "benign carcinomas as they had distinct clinical entities and named them "karzinoide"(carcinoma-like).
- Karzinoide or “carcinoma-like” describes the unique feature of behaving like a benign tumor despite resembling a carcinoma microscopically.
- Rapport and colleagues isolated and named serotonin (5-HT), initially identified as a vasoconstrictor substance in the serum.[2]
- Enterochromaffin cell, the carcinoid cell of origin, had been identified as early as 1897 by N. Kulchitsky (1856-1925).
- F. Lembeck in 1953 established that enterochromaffin cells synthesizes and secretes serotonin--a potent bioactive amine.[3]
References
- ↑ Tsoucalas G, Karamanou M, Androutsos G (2011). "The eminent German pathologist Siegfried Oberndorfer (1876-1944) and his landmark work on carcinoid tumors". Ann Gastroenterol. 24 (2): 98–100. PMC 3959292. PMID 24713679.
- ↑ RAPPORT MM, GREEN AA, PAGE IH (December 1948). "Serum vasoconstrictor, serotonin; isolation and characterization". J. Biol. Chem. 176 (3): 1243–51. PMID 18100415.
- ↑ ERSPAMER V, ASERO B (May 1952). "Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine". Nature. 169 (4306): 800–1. PMID 14941051.