Peptic ulcer laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Guillermo Rodriguez Nava, M.D. [2] Manpreet Kaur, MD [3]

Overview

In patients with peptic ulcer who are unstable rapid assessment and resuscitation should be initiated even before diagnostic evaluation. Once hemodynamic stability is achieved, a proper clinical history, physical examination, and initial laboratory findings are crucial not only in determining the likely sources of bleeding but also in directing the appropriate intervention. In acute ulcer bleeding, initial hematocrit level measured will not accurately reflect the amount of blood loss. Laboratory findings of peptic ulcer bleeding include anemia, coagulopathy, and an elevated BUN-to-creatinine ratio.

Initial Laboratory Studies

• There are no diagnostic laboratory findings associated with peptic ulcer disease.
• If there is the history of peptic ulcer disease then following laboratory test can be useful:
• Complete blood count
• Serum lipase and amylase
• Iron studies
• Some patients with Peptic ulcer disease may have reduced serum ferritin, which is usually suggestive of bleeding which suggests mandatory endoscopy