Non-Hodgkin lymphoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]

Overview

Other diagnostic studies for the diagnosis of non-Hodgkin lymphoma include bone marrow aspiration, bone marrow biopsy, and lumbar puncture.

Indications

Aggressive Non Hodgkin Lymphoma with involvement of bone marrow, epidural, testicular, paranasal sinus, or nasopharyngeal involvement, or two or more extranodal sites
High-grade lymphoblastic lymphoma
High-grade small noncleaved cell lymphomas (eg, Burkitt and non-Burkitt types)
HIV-related lymphoma
Primary CNS lymphoma
when neurologic signs and symptoms are present

It provides information about lineage and clonality and useful for subclassifying certain lymphoma subtypes which may provide therapeutic and prognostic importance.