Polycythemia vera risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Common risk factors in the development of polycythemia vera are a positive history of thrombotic event and old age ( 65 year old and older).[1]
Common Risk Factors
Common risk factors in the development of polycythemia vera are:[1]
- A positive history of thrombotic event
- Old age ( 65 year old and older)
The risk factors for the development of myelofibrosis from polycythemia vera include:
- Increased age
- Leukocytosis
- High variant allele frequency of the JAK2 mutation (high allele burden)
- Thrombocytosis
- Splenomegaly
The risk factors for the development of acute myeloid leukemia from polycythemia vera include:
- Increased age
- Leukocytosis
- Splenomegaly
- Abnormal karyotype
References
- ↑ 1.0 1.1 Barbui T, Carobbio A, Rumi E, Finazzi G, Gisslinger H, Rodeghiero F; et al. (2014). "In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology". Blood. 124 (19): 3021–3. doi:10.1182/blood-2014-07-591610. PMID 25377561.