Tumor lysis syndrome laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [3]
Overview
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum uric acid, potassium, phosphorus, and lactate dehydrogenase. Another laboratory abnormality is low calcium.[1]
Laboratory Findings
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:[1][2]
- Blood:
- Hyperuricemia ≥ 476 μmol/l
- Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults)
- Hyperkalemia ≥ 6·0 mmol/l
- Hypocalcemia ≤ 1·75 mmol/l
- Creatinine ≥1.5 x ULN
- Lactate dehydrogenase > ULN
- Metabolic acidosis
- Low urine output
- Uric acid crystals or amorphous urates
- High uric acid-creatinine ratio > 1.0
References
- ↑ 1.0 1.1 Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.
- ↑ Coiffier B, Altman A, Pui CH, Younes A, Cairo MS (2008). "Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review". J Clin Oncol. 26 (16): 2767–78. doi:10.1200/JCO.2007.15.0177. PMID 18509186.