S100A12

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. It is also known as calgranulin C and belong to the S100 protein family

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.

Further reading

• Roth J, Vogl T, Sorg C, Sunderkötter C (April 2003). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends in Immunology. 24 (4): 155–8. doi:10.1016/S1471-4906(03)00062-0. PMID 12697438.
• Guignard F, Mauel J, Markert M (July 1995). "Identification and characterization of a novel human neutrophil protein related to the S100 family". The Biochemical Journal. 309 ( Pt 2) (2): 395–401. PMC 1135745. PMID 7626002.
• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (February 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
• Yamamura T, Hitomi J, Nagasaki K, Suzuki M, Takahashi E, Saito S, Tsukada T, Yamaguchi K (April 1996). "Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping". Biochemical and Biophysical Research Communications. 221 (2): 356–60. doi:10.1006/bbrc.1996.0600. PMID 8619860.
• Marti T, Erttmann KD, Gallin MY (April 1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochemical and Biophysical Research Communications. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID 8619876.
• Ilg EC, Troxler H, Bürgisser DM, Kuster T, Markert M, Guignard F, Hunziker P, Birchler N, Heizmann CW (August 1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry". Biochemical and Biophysical Research Communications. 225 (1): 146–50. doi:10.1006/bbrc.1996.1144. PMID 8769108.
• Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt AM (June 1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889–901. doi:10.1016/S0092-8674(00)80801-6. PMID 10399917.
• Moroz OV, Antson AA, Dodson GG, Wilson KS, Skibshoj I, Lukanidin EM, Bronstein IB (February 2000). "Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12". Acta Crystallographica Section D. 56 (Pt 2): 189–91. doi:10.1107/S0907444999014936. PMID 10666601.
• Moroz OV, Antson AA, Murshudov GN, Maitland NJ, Dodson GG, Wilson KS, Skibshøj I, Lukanidin EM, Bronstein IB (January 2001). "The three-dimensional structure of human S100A12". Acta Crystallographica Section D. 57 (Pt 1): 20–9. doi:10.1107/S090744490001458X. PMID 11134923.
• Cole AM, Kim YH, Tahk S, Hong T, Weis P, Waring AJ, Ganz T (August 2001). "Calcitermin, a novel antimicrobial peptide isolated from human airway secretions". FEBS Letters. 504 (1–2): 5–10. doi:10.1016/S0014-5793(01)02731-4. PMID 11522286.
• Moroz OV, Antson AA, Dodson EJ, Burrell HJ, Grist SJ, Lloyd RM, Maitland NJ, Dodson GG, Wilson KS, Lukanidin E, Bronstein IB (March 2002). "The structure of S100A12 in a hexameric form and its proposed role in receptor signalling". Acta Crystallographica Section D. 58 (Pt 3): 407–13. doi:10.1107/S0907444901021278. PMID 11856825.
• Strauss GI, Edvinsson L, Larsen FS, Møller K, Knudsen GM (2002). "Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure". Neuropeptides. 35 (3–4): 174–80. doi:10.1054/npep.2001.0861. PMID 11884208.
• Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides. 35 (3–4): 189–95. doi:10.1054/npep.2001.0863. PMID 11884210.
• Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (August 2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". The Journal of Biological Chemistry. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
• Ryckman C, Robichaud GA, Roy J, Cantin R, Tremblay MJ, Tessier PA (September 2002). "HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes". Journal of Immunology. 169 (6): 3307–13. doi:10.4049/jimmunol.169.6.3307. PMID 12218151.
• Foell D, Ichida F, Vogl T, Yu X, Chen R, Miyawaki T, Sorg C, Roth J (April 2003). "S100A12 (EN-RAGE) in monitoring Kawasaki disease". Lancet. 361 (9365): 1270–2. doi:10.1016/S0140-6736(03)12986-8. PMID 12699958.
• Foell D, Kucharzik T, Kraft M, Vogl T, Sorg C, Domschke W, Roth J (June 2003). "Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease". Gut. 52 (6): 847–53. doi:10.1136/gut.52.6.847. PMC 1773692. PMID 12740341.