CUGBP2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the CELF2 gene.[1][2][3]

Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

Interactions

CUGBP2 has been shown to interact with A1CF.[4]

References

  1. Hwang DM, Hwang WS, Liew CC (Mar 1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system". J Mol Cell Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393.
  2. Lu X, Timchenko NA, Timchenko LT (Mar 1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy". Hum Mol Genet. 8 (1): 53–60. doi:10.1093/hmg/8.1.53. PMID 9887331.
  3. 3.0 3.1 "Entrez Gene: CELF2 CUGBP, Elav-like family member 2".
  4. Anant, S; Henderson J O; Mukhopadhyay D; Navaratnam N; Kennedy S; Min J; Davidson N O (Dec 2001). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. United States. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. ISSN 0021-9258. PMID 11577082.

External links

Further reading