Coiled-Coil Domain Containing protein 82 (CCDC82) is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.
CCDC82 is located on chromosome 11 at 11q21.5.[1]
It contains two domains of unknown function, DUF4196 and DUF4211.[2] The DNA sequence is 37,155 base pairs long[3] and contains 7 exons.[4]
The predicted promoter for CCDC82 is located on the minus strand and spans from base pairs 96,122,963 to 96,123,587. It is 625 base pairs long.[6]
Transcription factors
The transcription factors listed below are for the predicted promoter sequence and are located on the minus strand.[7]
Detailed Family Information
Span
Score
Alternative splicing variant of FOXP1
48-64
1.00
Homeodomain transcription factor Otx2
34-50
.992
Hypoxia-response Elements
111-127
.985
Homeobox A10/HOX 1.8
52-68
.957
SRY box 9
80-104
.947
Mesoderm posterior 1 and 2
42-62
.937
c-Myc/Max heterodimer
44-60
.929
SAM pointed domain containing ets transcription factor
27-47
.923
cAMP-responsive element binding protein
134-154
.917
PR domain zinc finger protein 14
138-152
.912
Protein
The protein it encodes for is 344 amino acids in length. The protein itself is very acidic and is very rich in aspartic acid and glutamic acid. It is also very deficient in alanine, containing only two alanines in the entire sequence. The alanines are located adjacent to each other, amino acid number 233 and 234. Alanine 233 is highly conserved throughout the orthologs. The molecular weight is 40.0 kdal and the isoelectric point is 4.383[8]
Expression
File:CCDC82ExpressionData.pngThis image shows the level of expression of CCDC82 in different tissues throughout the body.
CCDC82 is known to interact with two proteins. It indirectly interacts with VHL, a gene that encodes for a tumor suppressor and ubiquitin protein ligase. It also interacts with EWSR1, which functions as a transcriptional repressor.[13]
Clinical significance
CCDC82 is a circulat-responsive gene.[14] Circulat is a product designed to restore systemic vascular health. It is a plant based product and taken by patients who suffer from diabetes or circulatory problems.[15]
Possible function
Based on the information that CCDC82 is affected by the Circulat product it could be hypothesized that CCDC82 is involved in circulatory function. However, this is purely speculation.
↑Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
↑"CCDC82". NetPhos 2.0. Center for Biological Analysis.
↑"CCDC82". Gene Cards. Weizmann Institute of Science. Retrieved 2 May 2013.
↑Antoshechkin A, Olalde J, Magarici M, Muhammad A, Salom A, Suarez J, Amendola F (August 2007). "Analysis of effects of the herbal preparation Circulat on gene expression levels in cultured human fibroblasts". Phytother Res. 21 (8): 777–89. doi:10.1002/ptr.2174. PMID17514633.
