H1FNT
| H1 histone family, member N, testis-specific | |
|---|---|
| Identifiers | |
| Symbol | H1FNT |
| Alt. symbols | HANP1, H1T2 |
| Entrez | 341567 |
| HUGO | 24893 |
| RefSeq | NM_181788 |
| UniProt | Q75WM6 |
| Other data | |
| Locus | Chr. 12 q13.11 |
H1 histone family, member N, testis-specific is a member of the histone family of nuclear proteins which are a component of chromatin. In humans, this protein is encoded by the H1FNT gene.[1]
The H1FNT protein is essential for nuclear formation in spermatozoa, and is involved in the replacement of histones with protamines during spermiogenesis.[2]
References
- ↑ Martianov I, Brancorsini S, Catena R, et al. (February 2005). "Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2808–13. doi:10.1073/pnas.0406060102. PMC 549447. PMID 15710904.
- ↑ Tanaka H, Matsuoka Y, Onishi M, Kitamura K, Miyagawa Y, Nishimura H, Tsujimura A, Okuyama A, Nishimune Y (April 2006). "Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein". International Journal of Andrology. 29 (2): 353–9. doi:10.1111/j.1365-2605.2005.00600.x. PMID 16533358.
External links
- H1FNT+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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