MLST8

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.[1] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.[2] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.[3]

References

  1. "Entrez Gene: MTOR associated protein".
  2. "UniProtKB – Q9BVC4 (LST8_HUMAN)".
  3. Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 Apr 2015). "mLST8 Promotes mTOR-Mediated Tumor Progression". PLOS ONE. doi:10.1371/journal.pone.0119015.

Further reading