Hepatocellular carcinoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2] Mohamad Alkateb, MBBCh [3]
Overview
Common risk factors in the development of hepatocellular carcinoma are chronic hepatitis B, chronic hepatitis C, cirrhosis, and inherited metabolic diseases.
Common Risk Factors
Common risk factors that may increase the risk of developing hepatocellular carcinoma are:[1][2]
- Chronic hepatitis B
- Chronic hepatitis C
- Cirrhosis
- Inherited metabolic diseases such as hemochromatosis, tyrosinemia, alpha1-antitrypsin deficiency, porphyria cutanea tarda, glycogen storage diseases, and Wilson disease
- Diabetes Mellitus
- Nonalcoholic steatohepatitis
Less Common Risk Factors
Less common risk factors that may increase the risk of developing hepatocellular carcinoma are:[3][4][5]
- Anabolic steroids
- Arsenic
- Vinyl chloride and thorium dioxide
- Obesity
- Smoking
- Alcohol
- Food infected with Aspergillus flavus (especially peanuts and corns stored during prolonged wet seasons), which produces aflatoxin
References
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/liver/hp/adult-liver-treatment-pdq
- ↑ Trichopoulos D, Bamia C, Lagiou P, Fedirko V, Trepo E, Jenab M, Pischon T, Nöthlings U, Overved K, Tjønneland A, Outzen M, Clavel-Chapelon F, Kaaks R, Lukanova A, Boeing H, Aleksandrova K, Benetou V, Zylis D, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Bueno-De-Mesquita HB, Van Kranen HJ, Peeters PH, Lund E, Quirós JR, González CA, Sanchez Perez MJ, Navarro C, Dorronsoro M, Barricarte A, Lindkvist B, Regnér S, Werner M, Hallmans G, Khaw KT, Wareham N, Key T, Romieu I, Chuang SC, Murphy N, Boffetta P, Trichopoulou A, Riboli E (2011). "Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study". J. Natl. Cancer Inst. 103 (22): 1686–95. doi:10.1093/jnci/djr395. PMC 3216968. PMID 22021666.
- ↑ Clavière C, Bronowicki JP, Hudziak H, Bigard MA, Gaucher P (1998). "[Role of sex steroids and their receptors in the pathophysiology of hepatocellular carcinoma]". Gastroenterol. Clin. Biol. (in French). 22 (1): 73–86. PMID 9762169.
- ↑ "Studies of Cancer in Humans - Tobacco Smoke and Involuntary Smoking - NCBI Bookshelf".
- ↑ "Tobacco smoke and involuntary smoking". IARC Monogr Eval Carcinog Risks Hum. 83: 1–1438. 2004. PMC 4781536. PMID 15285078.