Lactose intolerance other diagnostic studies

	Lactose Intolerance Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Lactose Intolerance from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Lactose intolerance other diagnostic studies On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Lactose intolerance other diagnostic studies All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Lactose intolerance other diagnostic studies
CDC on Lactose intolerance other diagnostic studies
Lactose intolerance other diagnostic studies in the news
Blogs on Lactose intolerance other diagnostic studies
Directions to Hospitals Treating Lactose intolerance
Risk calculators and risk factors for Lactose intolerance other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Lactose tolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include bloating, diarrhea and abdominal pain and rising of blood glucose by less than 20 mg/dL after the ingestion of lactose. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC genotype at -13.9 kb upstream of the lactase gene.

Other Diagnostic Studies

Other diagnostic studies for lactose intolerance include:

Lactose tolerance test^[1]
Genetic test for primary lactase deficiency ^[2]

Lactose tolerance test

50 g of oral lactose in adults (2 g/kg in children) is administered and blood glucose levels are checked at 0, 60, and 120 minutes after the ingestion.
- Symptoms such as bloating, diarrhea and abdominal pain and rising of blood glucose by less than 20 mg/dL (1.1 mmol/L) are diagnostic for lactose intolerance.
- This test is used less than lactose breath hydrogen test because it needs repeated measurements of blood glucose level
False negative results cab be obtained due to
- Diabetes
- Bacterial overgrowth

Genetic test for primary lactase deficiency

Acquired primary lactase deficiency is associated with a CC genotype at -13.9 kb upstream of the lactase gene and lactase persistence is related to TT genotype.^[2]

References

↑ Law D, Conklin J, Pimentel M (2010). "Lactose intolerance and the role of the lactose breath test". Am. J. Gastroenterol. 105 (8): 1726–8. doi:10.1038/ajg.2010.146. PMID 20686460.
↑ ^2.0 ^2.1 Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL (2004). "A genetic test which can be used to diagnose adult-type hypolactasia in children". Gut. 53 (11): 1571–6. doi:10.1136/gut.2004.040048. PMC 1774274. PMID 15479673.

Template:WH Template:WS

[pmid20686460-1] Law D, Conklin J, Pimentel M (2010). "Lactose intolerance and the role of the lactose breath test". Am. J. Gastroenterol. 105 (8): 1726–8. doi:10.1038/ajg.2010.146. PMID 20686460.

[pmid15479673-2] 2.0 ^2.1 Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Tötterman N, Lindahl H, Järvelä I, Kolho KL (2004). "A genetic test which can be used to diagnose adult-type hypolactasia in children". Gut. 53 (11): 1571–6. doi:10.1136/gut.2004.040048. PMC 1774274. PMID 15479673.

[1]

[2]