Bowel obstruction pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
It is thought that bowel obstruction is the result of an obstruction that may occur extrinsically, intrinsically or intraluminally.
Pathophysiology
Pathogenesis
- Normally, the small intestine functions to pass gastrointestinal contents for absorption. The large surface area provided by the villi, plicae circularis and valvulae conniventes allow for this exchange to happens.
- In addition, the small bowel is free of microbes, in comparison to the large bowel that houses commensal flora that facilitate digestion and vitamin synthesis, namely vitamin K.
- Continuous transit throughout the bowel is important to prevent bowel dilatation, ischemia and necrosis.
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].