Sialadenosis pathophysiology
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Risk calculators and risk factors for Sialadenosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
It is thought that sialolithiasis is the result of calculi obstruction in the salivary glands.
Component of salivary stones include: [1]
- Calcium phosphate
- Hydroxyapatite
- Magnesium,
- Ammonium
- Potassium
The three major salivary glands (parotid, submandibular, and sublingual), and occasionally the minor salivary glands, are subject to the development of stones
Parotid, submandibular, and sublingual glands and minor salivary glands are prone to the development of stones.
Parotid glands and stensen ducts are located anterior to the external auditory canal.
Submandibular glands and wharton ducts are located beneath the floor of the mouth.
Sublingual glands are located beneath the mucous membrane of the floor of the mouth.
75 percent of sialadenosis cases are single [2][3]
3 percent of stones are bilateral and most of them are located in parotid glands.
Submandibular stones are the largest ones and are often located in the wharton ducts.
Parotid stones are the smaller ones, and they are more located within the glands.
Stone formation is more in the submandibular gland.
Stones occur equally on the right and left sides.
- The exact pathogenesis of [disease name] is not fully understood.
OR
- It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].