Neonatal jaundice natural history, complications and prognosis
|
Neonatal jaundice Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Neonatal jaundice natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Neonatal jaundice natural history, complications and prognosis |
|
FDA on Neonatal jaundice natural history, complications and prognosis |
|
on Neonatal jaundice natural history, complications and prognosis |
|
Neonatal jaundice natural history, complications and prognosis in the news |
|
Blogs on Neonatal jaundice natural history, complications and prognosis |
|
Risk calculators and risk factors for Neonatal jaundice natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Naturla history, complicaions and prognosis
Natural history
- If left untreated, neonatal jaundice may develop bilirubin related encephalopathy.
Complications
- Common complications of neonatal jaundice include the following:
- Acute bilirubin encephalopathy:[1][2][3]
- Bilirubin is toxic to the brain and high levels may cause acute bilirubin encephalopathy.
- In the beginning, it may be asymptomatic or the infant is sleepy and hypotonic.
- If the encephalopathy not diagnosed early, more complications will develop as lethargy, seizures, inability to feed, and apnea in severe cases.
- It is better to diagnose it early in order not to develop severe cases of encephalopathy.
- Kernicterus:The effects of kernicterus range from fever, seizures, and a high-pitched crying to mental retardation. This is due to a staining effect on the basal ganglia leading to neuronal damage. With aggressive treatment such as exchange transfusion to lower very high bilirubin levels, the neurological effects are almost always transient.
- Acute bilirubin encephalopathy:[1][2][3]
Prognosis
- Prognosis of neonatal jaundice is excellent with receiving the proper treatment.
References
- ↑ Chuniaud L, Dessante M, Chantoux F, Blondeau JP, Francon J, Trivin F (1996). "Cytotoxicity of bilirubin for human fibroblasts and rat astrocytes in culture. Effect of the ratio of bilirubin to serum albumin". Clin Chim Acta. 256 (2): 103–14. PMID 9027422.
- ↑ Bratlid D (1990). "How bilirubin gets into the brain". Clin Perinatol. 17 (2): 449–65. PMID 2196140.
- ↑ Hoffman DJ, Zanelli SA, Kubin J, Mishra OP, Delivoria-Papadopoulos M (1996). "The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor/ion channel complex in the brains of newborn piglets". Pediatr Res. 40 (6): 804–8. doi:10.1203/00006450-199612000-00005. PMID 8947954.