Hepatomegaly
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Hepatomegaly Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Iqra Qamar M.D.[2] Cafer Zorkun, M.D., Ph.D. [3]
Synonyms and keywords: Enlarged liver; liver enlargement
Overview
Causes
Hepatomegaly may be classified on the basis of etiology into hepatitis, storage disorders, impaired venous outflow, infiltrative and obstructive causes.[1][2][3][4][5][6][7][8][9][10][11][12]
| Etiology | Disease | |
|---|---|---|
| Hepatitis | Infections | Acute and chronic viral hepatitis |
| Bacterial liver abscess | ||
| Parasitic infections | ||
| Granulomatous hepatitis | ||
| Ischemia | Ischemic hepatitis ("shock liver") | |
| Toxins | Alcoholic hepatitis | |
| Steatosis | Alcoholic fatty liver disease | |
| Nonalcoholic steatohepatitis | ||
| Drugs/Medications | Drug induced liver injury (DILI) | |
| Immune mediated hepatitis | Autoimmune hepatitis | |
| Copper deposition | Wilson disease | |
| Storage disorders | Glycogen | Glycogen storage disorders |
| Diabetes mellitus | ||
| Lipid | Gaucher disease | |
| Nonalcoholic steatohepatitis | ||
| Protein | Alpha-1 antitrypsin deficiency | |
| Iron | Hemochromatosis | |
| Impaired venous outflow | Cardiac | Right heart failure |
| Constrictive pericarditis | ||
| Hepatic vein | Hepatic vein thrombosis | |
| Inferior vena cava web | ||
| Intrahepatic | Sinusoidal obstruction syndrome | |
| Peliosis hepatis | ||
| Infiltrative diseases | Benign primary liver tumors | Hemangiomas |
| Adenomas | ||
| Focal nodular hyperplasia | ||
| Malignant primary liver tumors | Hepatocellular carcinoma | |
| Cholangiocarcinoma | ||
| Fibrolamellar carcinoma | ||
| Hemangioendothelioma | ||
| Metastatic/disseminated tumors | Myeloma | |
| Lymphoma | ||
| Leukemia | ||
| Metastatic solid tumors | ||
| Biliary obstruction | Primary biliary cirrhosis | |
| Primary sclerosing cholangitis | ||
| Biliary atresia | ||
| Other | Anatomic variations | Riedel's lobe |
| Cystic liver disease | Polycystic liver disease | |
| Caroli's disease | ||
Differential diagnosis
Patients with hepatomegaly need to be differentiated from other patients presenting with similar complaints such as abdominal pain.[1][2][3][4][5][6][7][8][9][10][11][12]
Abbreviations: RUQ= Right upper quadrant of the abdomen, LUQ= Left upper quadrant, LLQ= Left lower quadrant, RLQ= Right lower quadrant, LFT= Liver function test, SIRS= Systemic inflammatory response syndrome, ERCP= Endoscopic retrograde cholangiopancreatography, IV= Intravenous, N= Normal, AMA= Anti mitochondrial antibodies, LDH= Lactate dehydrogenase, GI= Gastrointestinal, CXR= Chest X ray, IgA= Immunoglobulin A, IgG= Immunoglobulin G, IgM= Immunoglobulin M, CT= Computed tomography, PMN= Polymorphonuclear cells, ESR= Erythrocyte sedimentation rate, CRP= C-reactive protein, TS= Transferrin saturation, SF= Serum Ferritin, SMA= Superior mesenteric artery, SMV= Superior mesenteric vein, ECG= Electrocardiogram, US = Ultrasound
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Diagnostic workup
References
- ↑ 1.0 1.1 Wolf AD, Lavine JE (2000). "Hepatomegaly in neonates and children". Pediatr Rev. 21 (9): 303–10. PMID 10970452.
- ↑ 2.0 2.1 Chau TN, Lai ST, Tse C, Ng TK, Leung VK, Lim W, Ng MH (2006). "Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A". Am. J. Gastroenterol. 101 (2): 292–6. doi:10.1111/j.1572-0241.2006.00416.x. PMID 16454833.
- ↑ 3.0 3.1 Bernstein DL, Hülkova H, Bialer MG, Desnick RJ (2013). "Cholesteryl ester storage disease: review of the findings in 135 reported patients with an underdiagnosed disease". J. Hepatol. 58 (6): 1230–43. doi:10.1016/j.jhep.2013.02.014. PMID 23485521.
- ↑ 4.0 4.1 Torbenson M, Chen YY, Brunt E, Cummings OW, Gottfried M, Jakate S, Liu YC, Yeh MM, Ferrell L (2006). "Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus". Am. J. Surg. Pathol. 30 (4): 508–13. PMID 16625098.
- ↑ 5.0 5.1 Chatila R, West AB (1996). "Hepatomegaly and abnormal liver tests due to glycogenosis in adults with diabetes". Medicine (Baltimore). 75 (6): 327–33. PMID 8982149.
- ↑ 6.0 6.1 Mukewar S, Sharma A, Lackore KA, Enders FT, Torbenson MS, Kamath PS, Roberts LR, Kudva YC (2017). "Clinical, Biochemical, and Histopathology Features of Patients With Glycogenic Hepatopathy". Clin. Gastroenterol. Hepatol. 15 (6): 927–933. doi:10.1016/j.cgh.2016.11.038. PMID 28043933.
- ↑ 7.0 7.1 Charrow J, Andersson HC, Kaplan P, Kolodny EH, Mistry P, Pastores G, Rosenbloom BE, Scott CR, Wappner RS, Weinreb NJ, Zimran A (2000). "The Gaucher registry: demographics and disease characteristics of 1698 patients with Gaucher disease". Arch. Intern. Med. 160 (18): 2835–43. PMID 11025794.
- ↑ 8.0 8.1 Drebber U, Kasper HU, Ratering J, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M (2008). "Hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases". Liver Int. 28 (6): 828–34. doi:10.1111/j.1478-3231.2008.01695.x. PMID 18312287.
- ↑ 9.0 9.1 Park MA, Mueller PS, Kyle RA, Larson DR, Plevak MF, Gertz MA (2003). "Primary (AL) hepatic amyloidosis: clinical features and natural history in 98 patients". Medicine (Baltimore). 82 (5): 291–8. doi:10.1097/01.md.0000091183.93122.c7. PMID 14530778.
- ↑ 10.0 10.1 Cooke CB, Krenacs L, Stetler-Stevenson M, Greiner TC, Raffeld M, Kingma DW, Abruzzo L, Frantz C, Kaviani M, Jaffe ES (1996). "Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin". Blood. 88 (11): 4265–74. PMID 8943863.
- ↑ 11.0 11.1 Long RG, Scheuer PJ, Sherlock S (1977). "Presentation and course of asymptomatic primary biliary cirrhosis". Gastroenterology. 72 (6): 1204–7. PMID 870368.
- ↑ 12.0 12.1 "EASL Clinical Practice Guidelines: management of cholestatic liver diseases". J. Hepatol. 51 (2): 237–67. 2009. doi:10.1016/j.jhep.2009.04.009. PMID 19501929.