Mesothelioma laboratory tests
|
Mesothelioma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Mesothelioma laboratory tests On the Web |
|
American Roentgen Ray Society Images of Mesothelioma laboratory tests |
|
Risk calculators and risk factors for Mesothelioma laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of mesothelioma include abnormal pleural fluid analysis (decreased pleural pH and pleural fluid/serum glucose ratio).The presence of serum biomarker megakaryocyte potentiating factor (MPF) is suggestive of malignant mesothelioma.
Laboratory Findings
Pleural Fluid Analysis
- Pleural fluid analysis, via thoracentesis, may be performed to help in the diagnosis of pleural mesothelioma.[1]
- Pleural mesothelioma is associated with decreased pleural pH (< 7.30) and decreased pleural fluid/serum glucose ratios.
- Pleural fluid cytology may or may not be positive for mesothelioma.[2]
Serum Biomarker
Fluorescence In Situ Hybridization (FISH)
- FISH may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.[3]
- Mutlitarget FISH assay may be used to detect chromosomal abberations (chromosomes 3, 7, 17, and 9p21).
- FISH technique may also be used to explore the alternative mechanism of tumor suppressor gene inactivation by methylation of p16, p14, and p15 gene in the pathogenesis of mesothelioma.[3]
References
- ↑ Gottehrer A, Taryle DA, Reed CE, Sahn SA (1991). "Pleural fluid analysis in malignant mesothelioma. Prognostic implications". Chest. 100 (4): 1003–6. PMID 1914546.
- ↑ Na MJ (2014). "Diagnostic tools of pleural effusion". Tuberc Respir Dis (Seoul). 76 (5): 199–210. doi:10.4046/trd.2014.76.5.199. PMC 4050067. PMID 24920946.
- ↑ 3.0 3.1 Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B; et al. (2010). "Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology". Chest. 138 (1): 137–44. doi:10.1378/chest.09-1951. PMID 20139227.