Altitude sickness pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Altitude sickness caused by an increase in pulmonary artery pressure due to the normal pulmonary vasoconstriction induced by hypoxia.
Pathophysiology
Abbreviations: CBV= Cerebral blood volume, CBF= Cerebral or coronary blood flow, Pcap= Pulmonary capillary pressure, HACE= High-altitude cerebral edema, HAPE= High-altitude pulmonary edema [1][2][3][4]
Altitude hypoxemia | |||||||||||||||||||||||||||||||||||
Brain | Lung | ||||||||||||||||||||||||||||||||||
Vasodilation | Uneven vasoconstriction | ||||||||||||||||||||||||||||||||||
↑CBV | ↑CBF | ↑PAP | |||||||||||||||||||||||||||||||||
Overperfusion | Focal/regional overperfusion | ||||||||||||||||||||||||||||||||||
↑Pcap | ↑Pcap | ||||||||||||||||||||||||||||||||||
Vasogenic edema | Capillary leak | ||||||||||||||||||||||||||||||||||
HACE | HAPE | ||||||||||||||||||||||||||||||||||
References
- ↑ Imray C, Wright A, Subudhi A, Roach R (2010). "Acute mountain sickness: pathophysiology, prevention, and treatment". Prog Cardiovasc Dis. 52 (6): 467–84. doi:10.1016/j.pcad.2010.02.003. PMID 20417340.
- ↑ Taylor AT (January 2011). "High-altitude illnesses: physiology, risk factors, prevention, and treatment". Rambam Maimonides Med J. 2 (1): e0022. doi:10.5041/RMMJ.10022. PMC 3678789. PMID 23908794.
- ↑ Hackett PH (1999). "High altitude cerebral edema and acute mountain sickness. A pathophysiology update". Adv. Exp. Med. Biol. 474: 23–45. PMID 10634991.
- ↑ Murdoch D (March 2010). "Altitude sickness". BMJ Clin Evid. 2010. PMC 2907615. PMID 21718562.