Parkinson's disease differential diagnosis
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Overview
Differential Diagnosis
Parkinson disease must be differentiated from other diseases that can mimic this disease clinically or radiologically such as:
Essential tremor
Essential tremor is demonstrated by bilateral resting tremor of arms, head, chin and trunk. Tremor of PD is action tremor and it seems to be easy to differentiate it from resting tremor of ET but sometimes we can see resting tremor in PD patient and conversely action tremor in ET patients.[1][2]
Scans without evidence of dopaminergic deficit (SWEDD)
Patients with scans without evidence of dopaminergic deficit have upper extremity resting tremor but their disease does not progress to the complete PD and there are no evidence of dopamine depletion in their NS.[3]
Dementia with Lewy bodies
Multiple system atrophy
Corticobasal degeneration
Progressive supranuclear palsy
Idiopathic and familial basal ganglia calcification
Other neurodegenerative disorders
Secondary parkinsonism
- Vascular parkinsonism
- Drug-induced parkinsonism
References
- ↑ Jankovic J, Schwartz KS, Ondo W (November 1999). "Re-emergent tremor of Parkinson's disease". J. Neurol. Neurosurg. Psychiatry. 67 (5): 646–50. PMC 1736624. PMID 10519872.
- ↑ Louis ED, Levy G, Côte LJ, Mejia H, Fahn S, Marder K (October 2001). "Clinical correlates of action tremor in Parkinson disease". Arch. Neurol. 58 (10): 1630–4. PMID 11594921.
- ↑ Schneider SA, Edwards MJ, Mir P, Cordivari C, Hooker J, Dickson J, Quinn N, Bhatia KP (November 2007). "Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs)". Mov. Disord. 22 (15): 2210–5. doi:10.1002/mds.21685. PMID 17712858.