Adult-onset Still's disease laboratory findings
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Adult-onset Still's disease |
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Differentiating Adult-onset Still’s Disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, inflammatory marker such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may be elevated. Complete blood count may show leukocytosis with a left shift (increased neutrophils), anemia, thrombocytosis or pancytopenia (in cases of hemophagocytic syndrome).
Laboratory Findings
Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, the following laboratory abnormalities may be observed:
Inflammatory markers
- Increased ferritin (greater than 5 times of upper limit of normal may aid in diagnosis- > 1000 ng/ml)
- Elevated ESR
- Elevated CRP
Complete blood count
- Leukocytosis with pre-dominant neutrophils (left shift)
- Anemia
- Thrombocytosis
- Pancytopenia (in case of hemophagocytic syndrome)
Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT)
- Increased in case of disseminated intravascular coagulation (DIC)
Liver function tests (LFTs)
- Increased lactic dehydrogenase
- Increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
- Increased γ‐glutamyltransferase
- Increased bilirubin