Chondroma natural history
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Chondroma Microchapters |
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Chondroma natural history On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] Soujanya Thummathati, MBBS [3]
Overview
Natural History
- Enchndromas usually diagnosed in third and fourth decade of life.
- Periosteal chondromas are frequently diagnosed in second or third decade of life.[1]
- Synovial chondromas can occur at any age with the peak incidence at fifth decade.
Complications
Common complications of chondroma include:[2][3][4][5]
- Malignant transformation into a low grade chondrosarcoma
- Growth disturbance
- Pathologic fracture, especially in short tubular
- Recurrence
Prognosis
- Benign chondromas have a good prognosis with aprropriate treatment.
- Most patients with chondroma under treatment remain asymptomatic and recur rarely.
References
- ↑ Weber KL, Raymond AK (2002). "Low-grade/dedifferentiated/high-grade chondrosarcoma: a case of histological and biological progression". Iowa Orthop J. 22: 75–80. PMC 1888368. PMID 12180616.
- ↑ Palaoglu S, Akkas O, Sav A (1988). "Chondroma of the cervical spine". Clin Neurol Neurosurg. 90 (3): 253–5. PMID 3197353.
- ↑ Müller PE, Dürr HR, Nerlich A, Pellengahr C, Maier M, Jansson V (June 2004). "Malignant transformation of a benign enchondroma of the hand to secondary chondrosarcoma with isolated pulmonary metastasis". Acta Chir. Belg. 104 (3): 341–4. PMID 15285552.
- ↑ Martin JA, Forest E, Block JA, Klingelhutz AJ, Whited B, Gitelis S, Wilkey A, Buckwalter JA (September 2002). "Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation". Cell Growth Differ. 13 (9): 397–407. PMID 12354749.
- ↑ Choi E, Wert M, Guerrieri C, Tucci J (November 2010). "A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma". Orthopedics. 33 (11): 845. doi:10.3928/01477447-20100924-24. PMID 21053879.