Takayasu's arteritis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2]
Overview
Common risk factors in the development of Takayasu's arteritis include genetic predisposition, female sex, age <40, asian ethnicity.
Risk Factors
Common Risk Factors
Common risk factors in the development of Takayasu's arteritis include:[1]
- Genetic predisposition
- Genetic factors:
- Takayasu arteritis has been associated with different human leucocyte antigen (HLA) alleles in different populations.
- In Japan and Korea there is a clear association with the extended haplotype: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901.
- Immunologic:
- Immunohistopathologic examination has shown that the infiltrating cells in aortic tissue mainly consist of killer cells, especially gamma delta T lymphocytes.
- Infectious agents:
- Genetic factors:
- Female sex
- Age <40
- Asian ethnicity
References
- ↑ Weyand CM, Goronzy JJ (July 2003). "Medium- and large-vessel vasculitis". N. Engl. J. Med. 349 (2): 160–9. doi:10.1056/NEJMra022694. PMID 12853590.