Chronic myelogenous leukemia historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
In the 1840s, the first cases of chronic myelogenous leukemia (splenomegaly with high leukocyte count) was reported in France, Germany, and Scotland. In 1960, the association of Philadelphia chromosome with the pathogenesis of chronic myelogenous leukemia was first discovered. In 1973, (9;22) translocation was first discovered. Definition of the breakpoint cluster region (BCR) on chromosome 22 was first reported in 1984 and the demonstration of the BCR-ABL transcript in CML was first discovered in 1985. From 1980 onwards allogeneic stem cell transplantation (SCT) became the treatment of choice for eligible patients. In 1998, the era of tyrosine kinase inhibitors (TKI) began.[1][2]
Historical Perspective
[1][2] Important dates in chronic myelogenous leukemia:
- In the 1840s, the first cases of chronic myelogenous leukemia was first reported.
- In 1960, Philadelphia chromosome was first discovered by Peter Nowell and David Hungerford.
- In 1973, (9;22) translocation was first discovered.
- From 1980, allogeneic stem cell transplantation (SCT) became the treatment of choice for eligible patients.
- In 1984, definition of the breakpoint cluster region on chromosome 22 was first reported.
- In 1985, the BCR-ABL transcript was first discovered.
- In 1998, the era of tyrosine kinase inhibitors (TKI) began.
References
- ↑ 1.0 1.1 Nowell PC (August 2007). "Discovery of the Philadelphia chromosome: a personal perspective". J. Clin. Invest. 117 (8): 2033–5. doi:10.1172/JCI31771. PMC 1934591. PMID 17671636.
- ↑ 2.0 2.1 Goldman JM (October 2010). "Chronic myeloid leukemia: a historical perspective". Semin. Hematol. 47 (4): 302–11. doi:10.1053/j.seminhematol.2010.07.001. PMID 20875546.