Wilms' tumor causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Wilms' tumor may be caused by either genetic mutations or chromosomal alterations.

Causes

• Genetic mutations:
  • Wilms tumor 1 gene (WT1)
  • WT2
  • WTX

• Other genes and chromosomal alterations:
  • 1q
  • 16q and 1p
  • CACNA1E
  • 7p21
  • SKCG-1
  • TP53 (tumor suppressor gene)
  • FBXW7
  • PTCH1
  • DICER1
  • MYCN