Dialysis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Dialysis Main Page |
Overview
Chronic kidney disease (CKD) prevalence has an incremental pattern worldwide due to increased rate of diabetes mellitus and hypertension as the leading causes of CKD, increasing life expectancy, and aging of the populations. On the other hand, acute kidney injury requires renal replacement therapy in certain circumstances. Dialysis is an intervention aiming to substitutes for solutes and removing extra fluids to help or substitute the failing kidneys. It is considered as a renal replacement therapy method which is indicated in certain condition depending on severity and chronicity of the underlying condition. In acute setting, refractory increased electrolytes and fluid overload are the most common indications for dialysis. eGFR is the determining factor to initiate dialysis in chronic kidney disease however, uremic symptoms are important to consider early versus late dialysis not only according to eGFR.
Starting indications
The decision to initiate dialysis or hemofiltration in patients with renal failure can depend on several factors.
Uremic Symptoms
The following table describe the uremic symptoms and signs according to National Kidney Foundation (NKF) KDOQI guidelines.[1][2]
| Uremia manifestations | |
|---|---|
| Sypmtoms | Signs |
| Fatigue | Seizure/change in seizure treshold |
| Lethargy | Amenorrhea |
| Confusion | Reduced core body temperature |
| Anorexia | Protein-energy wasting |
| Alteration in smelling and tasting senses | Insulin resistance |
| Cramps | Heightened catabolism |
| Restless legs | Serositis (pleuritis, pericarditis) |
| Sleep disturbances | Hiccups |
| Pruritus | Platelet dysfunction |
| Somnolence | |
Nutritional Status
Nutritional status of CKD patients should be assessed frequently. Many factors could be considered as indicator, such as normalized protein equivalent of nitrogen appearance (nPNA), subjective global assessment (SGA), assessment of body composition by bioelectrical impedance analysis (BIA), lean body mass, and serum albumin level. Deterioration of nutritional status which is considered as protein energy malnutrition, resistant to dietary supplementation is an indication for dialysis.[3][4][5][6][7]
- Acute Indications for Dialysis/Hemofiltration:
- 1) Hyperkalemia
- 2) Metabolic Acidosis
- 3) Fluid overload (which usually manifests as pulmonary oedema)
- 4) Uremic pericarditis, a potentially life threatening complication of renal failure
- 5) And in patients without renal failure, acute poisoning with a dialysable drug, such as lithium, or aspirin.
- Chronic Indications for Dialysis:
- 1) Symptomatic renal failure.
- 2) Low glomerular filtration rate (GFR) (RRT often recommended to commence at a GFR of less than 10-15 mls/min/1.73m2)
- 3) Difficulty in medically controlling serum phosphorus or anaemia when the GFR is very low
Related Chapters
References
- ↑ Slinin Y, Greer N, Ishani A, MacDonald R, Olson C, Rutks I, Wilt TJ (November 2015). "Timing of dialysis initiation, duration and frequency of hemodialysis sessions, and membrane flux: a systematic review for a KDOQI clinical practice guideline". Am. J. Kidney Dis. 66 (5): 823–36. doi:10.1053/j.ajkd.2014.11.031. PMID 26498415.
- ↑ "KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 update". Am. J. Kidney Dis. 66 (5): 884–930. November 2015. doi:10.1053/j.ajkd.2015.07.015. PMID 26498416.
- ↑ Cano F, Azocar M, Cavada G, Delucchi A, Marin V, Rodriguez E (January 2006). "Kt/V and nPNA in pediatric peritoneal dialysis: a clinical or a mathematical association?". Pediatr. Nephrol. 21 (1): 114–8. doi:10.1007/s00467-005-2048-9. PMID 16208532.
- ↑ Moreau-Gaudry X, Jean G, Genet L, Lataillade D, Legrand E, Kuentz F, Fouque D (November 2014). "A simple protein-energy wasting score predicts survival in maintenance hemodialysis patients". J Ren Nutr. 24 (6): 395–400. doi:10.1053/j.jrn.2014.06.008. PMID 25194620.
- ↑ Segall L, Moscalu M, Hogaş S, Mititiuc I, Nistor I, Veisa G, Covic A (March 2014). "Protein-energy wasting, as well as overweight and obesity, is a long-term risk factor for mortality in chronic hemodialysis patients". Int Urol Nephrol. 46 (3): 615–21. doi:10.1007/s11255-014-0650-0. PMID 24474221.
- ↑ Beberashvili I, Azar A, Sinuani I, Kadoshi H, Shapiro G, Feldman L, Averbukh Z, Weissgarten J (March 2013). "Comparison analysis of nutritional scores for serial monitoring of nutritional status in hemodialysis patients". Clin J Am Soc Nephrol. 8 (3): 443–51. doi:10.2215/CJN.04980512. PMC 3586967. PMID 23411424.
- ↑ Zhang R, Ren YP (October 2012). "Protein-energy wasting and peritoneal function in elderly peritoneal dialysis patients". Clin. Exp. Nephrol. 16 (5): 792–8. doi:10.1007/s10157-012-0631-5. PMID 22526487.
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