Amyloidosis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Historical Perspective

• In 1639, Nicolaus Fontanus autopsied a young man who had ascites, jaundice, liver abscess and splenomegaly and his report has been the first description of amyloidosis.
• In 1854, Rudolph Virchow introduced the term of amyloid as an macroscopic abnormality in some tissues.
• In 1867, Weber reported the first case of amyloidosis associated with multiple myeloma.
• In 1922, Bennhold introduced Congo red staining of amyloid that remains the gold standard for diagnosis.
• In 1959, Cohen and Calkins used ultrathin sections of amyloidotic tissues and assessed by electron microscopic examination, explained the presence of nonbranching fibrils with indeterminate length and variable width.