Diffuse large B cell lymphoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Anila Hussain, MD [3]
Overview
According to the American Cancer Society, There are several Factors including Old Age, Male Gender, White Ethnicity, Geography, exposure to Certain Drugs and Chemicals, Radiation exposure, and weak Immune System that can increase the chances of getting Non Hodgkin Lymphoma(NHL) among which Diffuse Large B cell Lymphoma is the Most common sub-type.
Risk factors:
Age:
Old age is a strong risk Factor for Lymphoma Overall with majority of cases occurring in age 60 or more, however some cases can be seen in young population which depends upon the type of Lymphoma
Gender:
Overall Risk of Non-Hodgkin Lymphoma is higher in men than in women, but there are certain types that are more commonly seen in women. Reasons to these are unknown
Race, Ethnicity and Geography:
In USA, Non Hodgkin Lymphoma is most commonly seen in white population than African-Americans or Asian-Americans
Worldwide, it is more common in developed countries with USA and Europe having the highest prevalence.
Drug and Chemical Exposure:
Some chemicals like Benzene and Herbicides and Insecticides may be associated with an increase Risk of NHL but Research is under progress to clarify these links. Some Chemotherapeutic Drugs might be associated as treatment for Hodgkin Lymphoma increases the risk of NHL but it is unclear whether it is treatment related or related to disease itself
Radiation:
There is an increased risk of many types of cancers in people exposed to high intensity. For example Survivors of many nuclear reactor accidents and atomic bombs have found to have certain types of cancers including NHL, Leukemia and Thyroid cancer. Also people with Hodgkin Lymphoma who get treated with Radiation have a slightly increased incidence to develop NHL later in life
Immunodeficiency:
There is an increased risk of NHL in people with immunodeficiency. Examples include Organ Transplant Recipients who are on Immunosuppressive drugs, HIV Infection. Some genetic conditions in which children are born with weak immune system like Wiskott-Aldrich Syndrome and Ataxia-telengectasia(AT) also have higher risk of NHL.
Autoimmune:
Some autoimmune diseases also increase the risk of cancer slightly.