Diffuse large B cell lymphoma laboratory tests

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DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.

Laboratory tests of diffuse large B cell lymphoma include:

• Complete blood count (CBC)
• Comprehensive metabolic panel
• Blood chemistry studies including LDH and Uric acid
• Immunohistochemistry(IHC)
  • CD20, CD3, CD5, CD45, CD10, BCL-2, BCl-6, MYC, IRF-4/ MUM-1, Ki-67
• Flow Cytometry Panel (Establishing Reliable Diagnosis require IHC with or without Flow cytometry)
  • Kappa/ Lambda, CD3, CD5, CD45, CD10, CD19, CD20
• IHC for DLBCL subtypes:
  • Kappa/ Lambda, CD30, CD138, Cyclin/D1, ALK, HHV-8, SOX-11, EBER-ISH
• Cytology (for primary CNS lymphoma only)
• Genetic testing
  • 8q24/MYC translocations
  • Immunoglobulin genes clonally rearranged and hypermutated
  • Mutation of BCL6, MYC, PAX5, PIM1, RhoH/TTFn, TP53 genes
  • Translocations involving c-MYC, BCL6, and IgH genes

• Screening tests for HCV and HBV ( to assess risk of Reactivation following immunotherapy/ chemotherapy) are recommended.
• Screening test for HIV

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