Myeloproliferative neoplasm causes
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Myeloproliferative Neoplasm Microchapters |
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Differentiating myeloproliferative neoplasm from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Myeloproliferative neoplasm causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Myeloproliferative neoplasm is caused by mutations in various genes. Different gene mutations are responsible for each of the 8 subtypes of myeloproliferative neoplasms.[1][1] Importantly, multiple different gene mutations can cause a single disease.
Causes
| Myeloproliferative neoplasm subtype | Causative gene mutation |
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Polycythemia vera |
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Essential thrombocythemia |
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Primary myelofibrosis |
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Chronic myeloid leukemia |
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Chronic neutrophilic leukemia |
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Chronic eosinophilic leukemia |
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Myeloproliferative neoplasm, unclassifiable |
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Mastocytosis |
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References
- ↑ 1.0 1.1 Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera
- ↑ Antonioli E, Carobbio A, Pieri L, Pancrazzi A, Guglielmelli P, Delaini F; et al. (2010). "Hydroxyurea does not appreciably reduce JAK2 V617F allele burden in patients with polycythemia vera or essential thrombocythemia". Haematologica. 95 (8): 1435–8. doi:10.3324/haematol.2009.021444. PMC 2913097. PMID 20418246.
- ↑ Piazza R, Valletta S, Winkelmann N, Redaelli S, Spinelli R, Pirola A; et al. (2013). "Recurrent SETBP1 mutations in atypical chronic myeloid leukemia". Nat Genet. 45 (1): 18–24. doi:10.1038/ng.2495. PMC 3588142. PMID 23222956.
- ↑ Szuber N, Tefferi A (2018). "Chronic neutrophilic leukemia: new science and new diagnostic criteria". Blood Cancer J. 8 (2): 19. doi:10.1038/s41408-018-0049-8. PMC 5811432. PMID 29440636.
- ↑ 5.0 5.1 5.2 Falchi L, Verstovsek S (2015). "Eosinophilia in Hematologic Disorders". Immunol Allergy Clin North Am. 35 (3): 439–52. doi:10.1016/j.iac.2015.04.004. PMC 4515577. PMID 26209894.