Membranoproliferative glomerulonephritis (patient information)

Overview

Membranoproliferative glomerulonephritis ( MPGN ), also known as mesangiocapillary glomerulonephritis, is a type of  glomerulonephritis and an uncommon cause of chronic nephritis caused by dense deposits in the kidney glomerular mesangium. It can be subdivided into secondary and idiopathic forms, which can distinguished by clinical features, laboratory data and renal histopathology. Membranoproliferative glomerulonephritis is a type of  glomerulonephritis (GN), which can happen due to malfunction of immune system. Each individual immune system is responsible for fight against infections or other kind of disease to maintain health, inversely in autoimmune disorders such as MPGN, immune system starts to attack healthy cell same as what happen in MPGN and eventuate in destruction of kidney glomeruli.

What is the symptoms of Membranoproliferative glomerulonephritis?

The signs and symptoms of MPGN vary based on each individual and the type of MPGN occurred. It can be different from no symptoms to really obvious symptoms. These symptoms can included:

• Edema or swelling in feet, hands or face
  • Due to loss of protein in urine

• Turbid (cloudy) urine

• Blood in the urine (hematuria)
  • Maybe it can not be seen with naked eye
• Changes in mental status
• Decrease in urine volume