Urethral cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Urethral cancer may be classified based on histology into 3 sub types which include transitional cell carcinoma, squamous cell carcinoma, and adenocarcinoma. It may also be classified based on anatomical location of cancer into distal urethral cancer, proximal urethral cancer.

Classification

Based on histology

Urethral cancer can be classified based on histology into:

• Transitional cell (55%)
• Squamous cell (21.5%)
• Adenocarcinoma (16.4%)
• Melanoma

Based on anatomical location

Urethral cancer can also be classified based on anatomical location into:

• Distal Urethral Cancer:
  • Female: Distal third of the urethra
  • Males: Anterior, or penile portion of the urethra
• Proximal Urethral Cancer:
  • Females: Not limited to distal third
  • Male: Bulbomembranous and prostatic urethra

Distal	Proximal
Superficial lesions Distal third of the urethra in females In males: Anterior, or penile portion of the urethra	Deeply invasive. Not limited to distal third in females. Male: Bulbomembranous and prostatic urethra