Multiple myeloma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]
Overview
The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.
Causes
The causes of multiple myeloma include sporadic mutations and genetic predisposition. Mutations in tumor suppressors or oncogenes can cause multiple myeloma. Mutations in the tumor suppressor TP53 is most common. Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1] Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]
References
- ↑ 1.0 1.1 Rajkumar SV (2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.