Medullary sponge kidney differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]
Overview
Medullary sponge kidney must be differentiated from other diseases that may cause renal cysts, such as Autosomal dominant and autosomal recessive polycystic kidney disease, simple renal cysts, tuberous sclerosis complex, von Hippel-Lindau disease.
Differentiating medullary sponge kidney from other Diseases
Medullary sponge kidney must be differentiated from other diseases that may cause renal cysts, such as Autosomal dominant and autosomal recessive polycystic kidney disease, simple renal cysts, tuberous sclerosis complex, von Hippel-Lindau disease.
| Diseases | Clinical manifestations | Para–clinical findings | Gold standard | Additional findings | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical examination | |||||||||||
| Lab Findings | Imaging | Histopathology | ||||||||||
| Flank/abdominal pain | Polyuria | Hematuria | Hepatomegaly | Bilateral flank masses | Hypertension | Urinalysis | Ultrasound | CT scan | ||||
| Medullary sponge kidney[1][2] | + | +/– | + | – | + | – |
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– |
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| Autosomal dominant polycystic kidney disease (ADPKD)[3] | + | + | + | + | + | + |
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Ultrasound | Extrarenal manifestations: | ||
| Autosomal recessive polycystic kidney disease (ARPKD)[4] | + | + | + | + | + | + |
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Ultrasound | Extrarenal manifestations: | ||
| Simple renal cyst[5] | – | – | – | – | + | – | – |
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– |
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– |
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| Tuberous sclerosis complex[6][7] | +/– | +/– | +/– | – | + | – | – |
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– |
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| Von Hippel-Lindau disease[8][9] | + | +/– | + | – | + | – | – |
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CT scan | ||
References
- ↑ Gambaro G, Feltrin GP, Lupo A, Bonfante L, D'Angelo A, Antonello A (February 2006). "Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930s". Kidney Int. 69 (4): 663–70. doi:10.1038/sj.ki.5000035. PMID 16395272.
- ↑ Levine E, Hartman DS, Meilstrup JW, Van Slyke MA, Edgar KA, Barth JC (August 1997). "Current concepts and controversies in imaging of renal cystic diseases". Urol. Clin. North Am. 24 (3): 523–43. PMID 9275977.
- ↑ Gabow PA (July 1993). "Autosomal dominant polycystic kidney disease". N. Engl. J. Med. 329 (5): 332–42. doi:10.1056/NEJM199307293290508. PMID 8321262.
- ↑ Adeva M, El-Youssef M, Rossetti S, Kamath PS, Kubly V, Consugar MB, Milliner DM, King BF, Torres VE, Harris PC (January 2006). "Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD)". Medicine (Baltimore). 85 (1): 1–21. doi:10.1097/01.md.0000200165.90373.9a. PMID 16523049.
- ↑ Ravine D, Gibson RN, Donlan J, Sheffield LJ (December 1993). "An ultrasound renal cyst prevalence survey: specificity data for inherited renal cystic diseases". Am. J. Kidney Dis. 22 (6): 803–7. PMID 8250026.
- ↑ Umeoka S, Koyama T, Miki Y, Akai M, Tsutsui K, Togashi K (2008). "Pictorial review of tuberous sclerosis in various organs". Radiographics. 28 (7): e32. doi:10.1148/rg.e32. PMID 18772274.
- ↑ Manoukian SB, Kowal DJ (May 2015). "Comprehensive imaging manifestations of tuberous sclerosis". AJR Am J Roentgenol. 204 (5): 933–43. doi:10.2214/AJR.13.12235. PMID 25905927.
- ↑ Maher ER, Yates JR, Harries R, Benjamin C, Harris R, Moore AT, Ferguson-Smith MA (November 1990). "Clinical features and natural history of von Hippel-Lindau disease". Q. J. Med. 77 (283): 1151–63. PMID 2274658.
- ↑ Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, Oldfield EH (June 2003). "von Hippel-Lindau disease". Lancet. 361 (9374): 2059–67. doi:10.1016/S0140-6736(03)13643-4. PMID 12814730.