Angiomyolipoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

CT guided biopsy is diagnostic of angiomyolipoma.However it is used to established the diagnosis,when imaging modalities fails to establish the diagnosis especially in cases of fat poor Angiomyolipoma ^[1]that is difficult to distinguish from the Renal cell carcinoma.

Biopsy Findings

Biopsy findings of angiomyolipoma include:

Microscopic Features

Microscopic features of angiomyolipoma are:^[2]

Smooth muscle
Adipose tissue
Abundant blood vessels

Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[3]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[3]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[3]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain.^[3]

Cytologic

Cytologic features of angiomyolipoma include:^[2]

Nuclei - round/ovoid
Chromatin - bland

Immunohistochemistry

Immunohistochemistry markers of angiomyolipoma include:

Melanocytic markers positive^[4]
- HMB-45 positive in all cases (15/15)^[5]
- Melan A positive in ~87% of cases (13/15)
Epithelial markers negative^[4]
- EMA
- AE1/AE3
SMA positive
CD117 positive/negative
Ki-67:^[6]
- Epithelioid variant of angiomyolipoma positive
- Conventional angiomyolipoma negative

References

↑ Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA (2015). "Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation". Clin Radiol. 70 (2): 206–20. doi:10.1016/j.crad.2014.10.001. PMID 25468637.
↑ ^2.0 ^2.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter |month= ignored (help)
↑ ^3.0 ^3.1 ^3.2 ^3.3 http://librepathology.org/wiki/index.php/Angiomyolipoma
↑ ^4.0 ^4.1 Template:Ref GUP
↑ Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter |month= ignored (help)
↑ Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.

Template:WikiDoc Sources

[pmid25468637-1] Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA (2015). "Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation". Clin Radiol. 70 (2): 206–20. doi:10.1016/j.crad.2014.10.001. PMID 25468637.

[pmid15584043-2] 2.0 ^2.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter |month= ignored (help)

[aaa-3] 3.0 ^3.1 ^3.2 ^3.3 http://librepathology.org/wiki/index.php/Angiomyolipoma

[Ref_GUP324-4] 4.0 ^4.1 Template:Ref GUP

[pmid23932749-5] Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter |month= ignored (help)

[pmid18839327-6] Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.

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