Polycystic kidney disease historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]

Overview

In 1888, Fe´lix Lejars first used the term polycystic kidney^[1]
He also stressed on the fact these cysts are bilateral
In the late 18th century, Dr. Matthew Baillie noted that these cysts were vesicular and not hydatid, and named them false hydatids of kidney^[2]
In 1994, PKD-1 gene mutation on chromosome 16, was first implicated in the pathogenesis of ADPKD patients^[3]
Later PKHD1 gene mutation was found in patients with ARPKD

[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].

The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

There have been several outbreaks of [disease name], which are summarized below:

In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

The following are a few famous cases of Polycystic kidney disease:

King Stephen Bathory of Poland died from polycystic kidney disease in 1586^[4]
His death began the journey of the discovery of polycystic kidney disease as a disease process.

↑ Balat A (February 2016). "Tear drops of kidney: a historical overview of Polycystic Kidney Disease". G Ital Nefrol. 33 Suppl 66: 33.S66.21. PMID 26913889.
↑ BAILLIE, MATTHEW (2018). MORBID ANATOMY OF SOME OF THE MOST IMPORTANT PARTS OF THE HUMAN BODY. BY MATTHEW BAILLIE, ... THE... SECOND EDITION, CORRECTED AND CONSIDERABLY ENLARGE. S.l: GALE ECCO, PRINT EDITIONS. ISBN 1385243856.
↑ "Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium". Cell. 81 (2): 289–98. April 1995. PMID 7736581.
↑ Torres VE, Watson ML (October 1998). "Polycystic kidney disease: antiquity to the 20th century". Nephrol. Dial. Transplant. 13 (10): 2690–6. PMID 9794593.