Peripheral neuropathy natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
The symptoms of peripheral neuropathy usually start with symptoms such as numbness, prickling or tingling in feet or hands, which can spread upward into legs and arms. The symptoms of peripheral neuropathy typically develop five years after diagnosis of diabetes mellitus. Fifty percent of people with diabetes eventually develop diabetic peripheral neuropathy. Common complications of peripheral neuropathy include: Foot ulcers, Gangrene of the limbs from infected wounds, Amputation from infected wounds, Cardiovascular automatic neuropathy, Gastroparesis, Bladder control loss, Fecal incontinence and Ataxia and frequent falls. Peripheral neuropathy may worsen over time. Very few forms of peripheral neuropathy are fatal: Cardiac autonomic neuropathy is a frequent chronic complication of diabetes mellitus with potentially life-threatening outcomes.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of peripheral neuropathy usually start with symptoms such as numbness, prickling or tingling in feet or hands, which can spread upward into legs and arms.
- The symptoms of peripheral neuropathy typically develop five years after diagnosis of diabetes mellitus. Fifty percent of people with diabetes eventually develop diabetic peripheral neuropathy.
Complications
- Common complications of peripheral neuropathy include:[1][2][3][4][5][6][7]
- Foot ulcers
- Gangrene of the limbs from infected wounds
- Amputation from infected wounds
- Cardiovascular automatic neuropathy
- Gastroparesis
- Bladder control loss
- Fecal incontinence
- Ataxia and frequent falls
Prognosis
- Peripheral neuropathy may worsen over time.[1]
- Very few forms of peripheral neuropathy are fatal:[1]
- Cardiac autonomic neuropathy is a frequent chronic complication of diabetes mellitus with potentially life-threatening outcomes.[8][9]
References
- ↑ 1.0 1.1 1.2 Marchettini P, Lacerenza M, Mauri E, Marangoni C (2006). "Painful peripheral neuropathies". Curr Neuropharmacol. 4 (3): 175–81. PMC 2430688. PMID 18615140.
- ↑ Karabouta Z, Barnett S, Shield JP, Ryan FJ, Crowne EC (2008). "Peripheral neuropathy is an early complication of type 2 diabetes in adolescence". Pediatr Diabetes. 9 (2): 110–4. doi:10.1111/j.1399-5448.2007.00339.x. PMID 18221439.
- ↑ Greene DA, Sima AA, Stevens MJ, Feldman EL, Lattimer SA (1992). "Complications: neuropathy, pathogenetic considerations". Diabetes Care. 15 (12): 1902–25. PMID 1464245.
- ↑ Singh S, Chand G, Charan S, Arora S, Singh P (2013). "Peripheral arterial disease and digital gangrene: a rare presentation of diabetic hand syndrome". J Clin Diagn Res. 7 (10): 2286–7. doi:10.7860/JCDR/2013/5584.3498. PMC 3843397. PMID 24298503.
- ↑ Smith JK, Myers KP, Holloway RG, Landau ME (2014). "Ethical considerations in elective amputation after traumatic peripheral nerve injuries". Neurol Clin Pract. 4 (4): 280–286. doi:10.1212/CPJ.0000000000000049. PMC 4160445. PMID 25279253.
- ↑ Serhiyenko VA, Serhiyenko AA (2018). "Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment". World J Diabetes. 9 (1): 1–24. doi:10.4239/wjd.v9.i1.1. PMC 5763036. PMID 29359025.
- ↑ Burakgazi AZ, Alsowaity B, Burakgazi ZA, Unal D, Kelly JJ (2012). "Bladder dysfunction in peripheral neuropathies". Muscle Nerve. 45 (1): 2–8. doi:10.1002/mus.22178. PMID 22190298.
- ↑ Freeman R (2005). "Autonomic peripheral neuropathy". Lancet. 365 (9466): 1259–70. doi:10.1016/S0140-6736(05)74815-7. PMID 15811460.
- ↑ Pop-Busui R (2010). "Cardiac autonomic neuropathy in diabetes: a clinical perspective". Diabetes Care. 33 (2): 434–41. doi:10.2337/dc09-1294. PMC 2809298. PMID 20103559.