Spondyloarthropathy epidemiology and demographics

epidemiology and demographics

Spondyloarthropathy (SpA) is a world wide disease but it has been seen mostly throughout Europe, Asia, North Africa, and North America, which are the places for presence of HLA-B27. SpA and HLA-B27 is somehow absent among genetically unmixed native populations of South Africa and Australia.

Here are some labeled data that shows not only the prevalence of spondyloarthropathies but also the prevalence of HLA-B27 and its subtype.

Prevalence of AS and related spondyloarthropathies throughout different populations
populations	B27 frequency	Prevalence of AS		Prevalence of SpA (including AS)
		General population	B27+ part of population	General population	B27+ part of population
Eskimos (Alaska)	40%	0.4%	..	2.5%
Skimos (Alaska & Siberia) & Chukcki	25-40%	..	1.6%	2-3.4%	4.2%
Samis (Lapland)	24%	1.8%	6.8%	..	..
Northern Norway	10-16%	1.4%	..	..	..
Mordovia	16%	0.5%	..	..	..
Europe (Western)	8%	0.2%	2%	..	..

..