Thrombotic thrombocytopenic purpura classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

There is no established system for the classification of [disease name].

OR

[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].

OR

[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].

OR

Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.

OR

If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].

OR

The staging of [malignancy name] is based on the [staging system].

OR

There is no established system for the staging of [malignancy name].

Classification

TTP may be classified into several subtypes based on ADAMTS13 gene mutations and autoantibody(herditary syndromes) against ADAMTS13(aquired syndromes):

1.Hereditary:

• Congenital TTP
• Inherited TTP
• familial TTP
• Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34 .

2.Acquired

• Existence of an inhibitory antibody against ADAMS13 due to the variety of conditions.