Ascending cholangitis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Ascending cholangitis is a cholangitis caused by bacterial infection. Cholangitis, in turn, is an inflammation of the bile duct.[1]
Historical Perspective
Classification
Pathophysiology
Main factors that are involved in the pathogenesis of ascending cholangitis include obstruction of the biliary tract, increased intraluminal pressure and the infection of bile. Bacterial contamination alone in absence of obstruction does not usually result in cholangitis. However increased pressure within the biliary system (above 20 cmH2O)[2] resulting from obstruction in the bile duct widens spaces between the cells lining the duct, bringing bacterially contaminated bile in contact with the bloodstream while affecting the function of infection prevention macrophages (Kupffer cells) at the same time. In addition, high biliary pressure also spreads the infection into biliary canaliculi, hepatic veins and perihepatic lymph vessels resulting in bacteremia (bacteria in the bloodstream).
Causes
Any condition that leads to stasis or obstruction of bile in the common bile duct can lead to bacterial infection and cholangitis. Most common causes include bile duct stones and benign or malignant strictures. Less common causes include parasitic infection, malignancy, or extrinsic compression by the pancreas. Partial obstruction has a higher rate of infection as compared to complete obstruction[3]
Differentiating Ascending Cholangitis from Other Diseases
Ascending cholangitis must be differentiated from other diseases that cause abdominal pain and fever, such as acute cholecystitis, acute hepatitis, acute pancreatitis, diverticulitis, biliary leakage or stricture, hepatic abcess, duodenal and gastric ulcer, cholestatic liver disease and pancreatic cancer.
Epidemiology and Demographics
Ascending cholangitis is a relatively uncommon disease. It usually occurs following other diseases that lead to biliary infection and stasis. In the Western world, about 15% of all people have gallstones in their gallbladder but the majority are unaware of this and have no symptoms. Over ten years, 15–26% will suffer one or more episodes of biliary colic (abdominal pain due to the passage of gallstones through the bile duct into the digestive tract), and 2–3% will develop complications of obstruction: acute pancreatitis, cholecystitisor acute cholangitis[4]. 0.5-2.4 percent people can develop acute cholangitis following ERCP. Mortality rate of acute cholangitis after the year 2000 was found to be 2700-10,000 per 100,000 people[5]. More commonly seen in Latin-Americans and Native American, However anyone can be affected by the disease. Risk is higher in old age particularly more than 70 years of age[6]. Ascending cholangitis affects men and women equally although the gallstones are more frequently seen in women. Parasitic infections, specifically including the species Ascaris, Opisthorchis, Clonorchis, Fasciola and Echinococcus, are commonly associated with cholangitis outside of the United States.
Risk Factors
Common risk factors in the development of ascending cholangitis include bile duct stones, history of gall stones, biliary strictures, and biliary tract surgery. Less common factors include immunodeffeciency, comorbidities and sclerosing cholangitis. There is a higher risk of acute cholangitis in patients with advanced age (>70) and smoking[7].
Screening
Natural History, Complications, and Prognosis
The severity of ascending cholangitis can range anywhere from mild to life threatning and can be fatal if left untreated. Complications of acute cholangitis may include sepsis, hepatic abcesses, liver failure, renal failure, pancreatitis as well as postoperative complications like pneumonia,respiratory failure, heart failure, cardiac arrythmias, cardiac ischemia, gastrointestinal bleeding, bile leaking into peritoneum or abdomen, renal abcess, fistulae, wound infection, wound dehiscence and disseminated intravascular coagulation (DIC)[8]. Acute cholangitis bears a significant risk of death, with the leading cause being irreversible shock with multiple organ failure (which could have multiple possible complications of severe infections). Modern improvements in diagnosis and treatment have led to a reduction in mortality. Prognosis is good in patients who have quick and adequate drainage where there is improvement in hemodynamic and inflammatory parameters. Prognosis of disease depends on the severity of the illness. Poor outcomes are seen if urgent surgery is required for drainage
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment[edit | edit source]
Medical Therapy
Interventions
Surgery
Primary Prevention[
Secondary Prevention
References
- ↑ gpnotebook
- ↑ Huang T, Bass JA, Williams RD (1969). "The significance of biliary pressure in cholangitis". Arch Surg. 98 (5): 629–632. PMID 4888283. Unknown parameter
|month=ignored (help) - ↑ Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M; et al. (2007). "Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines". J Hepatobiliary Pancreat Surg. 14 (1): 15–26. doi:10.1007/s00534-006-1152-y. PMC 2784509. PMID 17252293.
- ↑ Bateson MC (1999). "Fortnightly review: gallbladder disease". BMJ. 318 (7200): 1745–8. PMC 1116086. PMID 10381713.
- ↑ Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ; et al. (2013). "TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis". J Hepatobiliary Pancreat Sci. 20 (1): 8–23. doi:10.1007/s00534-012-0564-0. PMID 23307004.
- ↑ Dageforde DA, Genovely HC, Goodin RR, Allen RD (1987). "Emergency percutaneous transluminal coronary angioplasty in acute myocardial infarction". J Ky Med Assoc. 85 (7): 368–72. PMID 2956349.
- ↑ Yeom DH, Oh HJ, Son YW, Kim TH (2010). "What are the risk factors for acute suppurative cholangitis caused by common bile duct stones?". Gut Liver. 4 (3): 363–7. doi:10.5009/gnl.2010.4.3.363. PMC 2956349. PMID 20981214.
- ↑ Lai EC, Tam PC, Paterson IA, Ng MM, Fan ST, Choi TK; et al. (1990). "Emergency surgery for severe acute cholangitis. The high-risk patients". Ann Surg. 211 (1): 55–9. PMC 1357893. PMID 2294844.